This data set contains a 12 km resolution, simulated reanalysis of aerosol transport, chemistry, and deposition over the High Mountain Asia (HMA) region for 1 January 2003 through 31 August 2019. Two-dimensional surface data are provided at one hour intervals. Three-dimensional atmospheric data are provided at three-hour intervals for 35 sigma levels extending from the surface to 50 hPa. Also known as the Model for Atmospheric Transport and Chemistry in Asia (MATCHA), the data comprise a wide range of variables intended to help assess the impacts of aerosols on the cryosphere in the HMA region, including: concentrations of black/brown carbon and other light absorbing particles (LAPs), broken out by source region; longwave/shortwave heating rates due to LAPs; wet/dry deposition of LAPs; precipitation and hydrological data; and meteorological state variables. The simulation was generated using a fully coupled, regional chemistry-climate model (WRF-Chem-CLM-SNICAR), constrained by aerosol optical depth (AOD) and carbon monoxide (CO) satellite observations acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) and Measurements Of Pollution In The Troposphere (MOPITT) instruments, respectively.